You
can call it Ozempic, Wegovy, or Rybelsus but these GLP-1 receptor agonists
(GLP-1RA) aren’t just Hollywood’s weight loss drugs! They’re one of the most
powerful medical breakthroughs in decades but reducing them to just a “weight
loss drug” misses the bigger story. I can see why most individuals would think
this, after all it’s the main thing being marketed. From celebrities like
Serena Williams and Charles Barkley on RO commercials, to Lizzo, Oprah and Elon
Musk weighing in, GLP-1RA have become synonymous with weight loss and this
perception risks fueling stigma against people who rely on them for serious
health conditions.
What are GLP-1 Receptor Agonists?
What exactly are GLP-1RA? Let’s break it down. Our body naturally produces a hormone, Glucagon- Like- Peptide-1 (GLP-1) at the arrival of food in the small intestine (6). A receptor is a protein that is on the inside or the surface of a cell that waits for a specific molecule to trigger an effect within the cell. These specific molecules are agonists that bind to the receptor (2). Agonists can be either natural hormones or drugs. Think of it like a house key (the natural hormone) and the drug is like a copy you made for your kids. It’s not the original but it still unlocks the door. So GLP-1RA are synthetic versions of the natural GLP-1 hormone but engineered to last much longer than natural GLP-1 like your kids keeping the door open longer.
Diabetes: The Bigger Picture
According
to the CDC, more than 38 million Americans (about 1 in 10) have diabetes with
90-95% having type 2 (8). In type 2 diabetes, the body’s cells resist insulin and
the pancreas overproduces it. This leads to more glucose being stored as fat.
From Pop Culture to Real Life
Many
people, like me, weren’t aware of the existence of these GLP-1RA. I only heard
of them last year when rapper
Drake was making fun of rapper Rick Ross claiming Ozempic has a side effect of
jealousy during their rap beef. When I didn’t understand the line initially, I
did my research and learned that Rick Ross once weighed over 400lbs and used
Ozempic to lose a significant portion of that weight. I didn’t know much about
these drugs at first only the surface level information about their weight loss
benefits. One of my coworkers, Miranda, told me about her reasonings and all
the things she has benefited from being on semaglutide (the active ingredient
in Ozempic and Wegovy) compounded with Vitamin B12. When I interviewed Miranda,
she said she started taking this medication because she had reached her highest
weight ever and experienced fatigue, shortness of breath, and lack of
endurance. She couldn’t do the things she enjoyed like playing with her nieces
and nephews. Between May and September 2024 Miranda tried a caloric deficit and
exercising regimen but unfortunately failed to see consistent results. It’s
been a year now since starting her journey with a GLP-1RA. She has lost over
70lbs so far and now has an improved and normal BMI. She has had a positive
experience so far, from improved bloodwork to improved joint pain and swelling
since GLP-1s may help in decreasing inflammation. Miranda says she has also
decreased her risk of chronic diseases like heart disease and diabetes.
Conclusions
Weight
loss has come a long way, and some people just can’t lose weight with diet and
exercise alone. While some may simply prefer the traditional method it is
ultimately a personal choice. Maybe it’s not just about lowering the number
on the scale, but about the individual’s health, energy, and showing up for
their family. All in all, GLP-1RA didn’t start out as weight loss drugs, this
just happened to be a great side effect of them. Their broader impact on health
and quality of life is what is making them some of the biggest medical
breakthroughs in our time.
By Said Zakaria, a Master's of Medical Science student at the University of Kentucky
Resources
1. Amylin Pharma, Inc., and Eli Lilly and Company. “Amylin and Lilly Announce FDA Approval of Byetta (Exenatide).” Amylin and Lilly Investor News Releases, 28 Apr. 2005, https://investor.lilly.com/news-releases/news-release-details/amylin-and-lilly-announce- fda-approval-byettatm-exenatide.
2. Baggio, Laurie L., and Daniel J.
Drucker. “Glucagon-like Peptide-1 Receptors in the Brain: Controlling Food
Intake and Body Weight.” Journal of Clinical Investigation, vol. 124, no. 10,
Sept. 2014, pp. 4223–26. https://doi.org/10.1172/jci78371.
3. Diabetes in America: Prevalence,
Statistics, and Economic Impact. https://diabetes.org/about-diabetes/statistics/about-diabetes.
4. GLP-1R and Diabetes. bpsbioscience.com/glp-1r-diabetes#ref6.
5. Higuera, Valencia. “What Is Insulin
Resistance? Causes, Symptoms, Diagnosis, Treatment, and Prevention.”
EverydayHealth.com, 17 Feb. 2023, www.everydayhealth.com/type-2-diabetes/insulin-resistance-causes-symptoms- diagnosis-consequences.
6. Muskiet, Marcel H. A., et al. “GLP-1
and the Kidney: From Physiology to Pharmacology and Outcomes in Diabetes.”
Nature Reviews Nephrology, vol. 13, no. 10, Sept. 2017, pp. 605–28. https://doi.org/10.1038/nrneph.2017.123.
7. Professional, Cleveland Clinic Medical.
“GLP-1 Agonists.” Cleveland Clinic, 30 June 2025, https://my.clevelandclinic.org/health/treatments/13901-glp-1-agonists.
8. “Type 2 Diabetes.” Diabetes, 15 May
2024, www.cdc.gov/diabetes/about/about-type-2- diabetes.html.
9. View of the Origins of Type 2 Diabetes
Medications | British Journal of Diabetes. https://bjd-abcd.com/index.php/bjd/article/view/1003/1239?utm_